Plasma Proteomics · Preventive Health

Know how your organs are changing.

A single blood draw measuring ~3,000 proteins reveals how your organs are aging biologically — flagging early signals of long-term disease risk years before symptoms appear. Every report is reviewed by a licensed clinician.

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Feb 2026
Overall Bio Age
40
Your age: 38
+2y
🧠Brain−1y
❤️Heart+5y
🟤Liver+5y
🫁Lung−2y
🫘Kidney0y
🩸Vascular+3y
🛡️Immune−1y
🔬Pancreas0y
← Dashboard kale.
🟤
Liver Health
Aging faster than average
43
Organ age
vs
38
Your age
+5y
Your Trajectory
Normal Yours
Today +5y 25 30 38 50 Chronological age →
Protein signals
Hepatic Metabolic Stress High
Hepatic Inflammation Elevated
Hepatic Fibrotic Signaling Normal
Research-grade population signals · not clinical diagnostics
Retests every 4–6 months
The science

The proteins in your blood reveal
what's actually happening in your biology.

Thousands of proteins circulate in your plasma right now — secreted by your organs, each carrying a molecular signal about the biological state of the organ it came from. For most of human history, we had no way to read those signals at scale. Kale was founded to bring this technology to people.

Organ aging clocks
what proteomics makes possible
Proteins secreted by your organs carry a molecular signature of each organ's biological state. Machine learning models trained on these signatures assign a biological age to each organ — distinct from your chronological age, and far more informative. Your heart may be aging slowly. Your liver may be aging fast. For the first time, we can see the difference.
5–15 years
of predictive lead time
Accelerated organ aging predicts heart failure, Alzheimer's disease, type 2 diabetes, and COPD 5 to 15 years before clinical diagnosis — independently validated across more than 140,000 individuals at Stanford, Harvard, and the Broad Institute. The signals are present long before symptoms appear. The window for intervention is wide open.
Kale
was founded to bring this to patients
This science exists in peer-reviewed journals. It has not existed as a consumer product. Kale was founded to change that — to take validated proteomic organ aging models and make them accessible, longitudinal, and actionable for anyone who wants a real window into how their biology is aging, and do something about it.
How it works

One blood draw.
Eight organ clocks.

No special equipment, no clinic visit. Standard lab infrastructure, extraordinary resolution.

01
Book a blood draw
A standard blood draw at a nearby lab — about 15 minutes. No special preparation required. Works with most existing lab networks.
02
We measure ~3,000 proteins
Your sample is analyzed using advanced proteomics, measuring proteins that reflect the current biological state of each organ system — not just whether they're damaged.
03
Your organ aging report
Results in about 2 weeks. Biological age scores for 8 organ systems, protein signals for liver and kidney, and a trajectory that builds with every retest.
The retest loop

Build a picture of how your biology is changing over time.

A single test tells you where you are. Repeated tests over time tell you where you're going. Organ aging is a slow process — trajectories emerge across months and years, not weeks. Each retest adds a data point that makes the picture sharper.

Most health tests give you a snapshot with no way to track change over time. Kale is designed to be longitudinal — the value compounds with each retest. Your organ aging scores, your protein signals, and your wearable data together build a biological record that gets more meaningful the longer you use it.

🩸
Blood
draw
📊
Organ
report
🎯
Take
action
🔁
Retest
4–6 months
Connects with
Apple Health Oura Whoop Garmin
🟤
Liver
Biological age over time
↓ Slowly improving
Your Trajectory
Normal Yours
+6y +4y +2y 0y estimated between tests +3.5y +5y Feb '26 Aug '26 Feb '27 Aug '27 Normal range Your liver biological age gap (estimated between tests)
Protein signals · Aug '27
Hepatic Metabolic Stress
was High Elevated
Hepatic Inflammation
was Elevated Elevated
Hepatic Fibrotic Signaling
was Normal Normal
18 months of retesting building a longitudinal picture. The organ age trajectory and protein signals together show direction over time — individual test-to-test variation is normal.
The Science

Peer-reviewed.
Validated at scale.

140k+
individuals across independent validation studies
~3,000
proteins measured per sample
8
organ systems scored at launch

Organ-level proteomic aging is one of the most replicated findings in recent biology. Protein signatures in your blood reflect the biological age of individual organs — and these signals predict major disease outcomes years before symptoms appear.

Nature Medicine
2025
Proteomic organ aging clocks predict heart failure, Alzheimer's, diabetes, and COPD years in advance
Oh, Rutledge, Wyss-Coray et al. (Stanford) · 44,498 individuals · UK Biobank
Nature Aging
2025
Validated organ aging clocks across ten systems in three independent cohorts
Wang et al. · 43,616 participants across UK, US, and Chinese cohorts
Cell Metabolism
2025
Lifestyle factors and medications associated with measurable shifts in organ aging trajectories
Goeminne, Argentieri, Gladyshev et al. (Harvard/Broad) · 53,000+ participants
At launch

8 organs. One test.

Your organ aging report covers the systems that matter most for long-term health. Each score shows how your organ's biological age compares to your chronological age.

❤️
Heart
At launch
🧠
Brain
At launch
🟤
Liver
At launch
🫘
Kidney
At launch
🫁
Lung
At launch
🛡️
Immune
At launch
🩸
Vascular
At launch
🔬
Pancreas
At launch
Protein signals

Deeper intelligence
from the same blood draw.

Beyond the organ aging score, Kale reports population-normalized protein signals — composites of proteins with established biological roles, showing where your levels sit relative to people your age and sex. These are research-grade signals, not clinical diagnostics.

🟤
Liver
3 protein signals
Hepatic Metabolic Stress
Proteins associated with hepatic fat metabolism and metabolic stress, including FGF21 and FABP1. Population-normalized composite.
Hepatic Inflammation
Proteins associated with hepatic inflammatory signaling, including GDF15 and CXCL10. Population-normalized composite.
Hepatic Fibrotic Signaling
Proteins associated with extracellular matrix remodeling in the liver, including TIMP-1. Population-normalized composite.
🫘
Kidney
2 protein signals
Renal Tubular Injury
KIM-1/HAVCR1 — an established tubular injury marker. Population-normalized.
Renal Tubular Function
UMOD (uromodulin) — a validated kidney function protein. Population-normalized.
🩸
Vascular
1 protein signal
Endothelial Activation
VCAM-1 and ICAM-1 — proteins associated with endothelial and vascular inflammatory signaling. Population-normalized composite.
How to read these

Each signal tells you where a group of biologically relevant proteins sits relative to people your age and sex in our reference population of 54,000+ individuals.

The signal names reflect established biological processes — the proteins in each composite have published associations with those processes in peer-reviewed literature.

These are research-grade population signals. They are not clinical diagnostic tests and should not be interpreted as diagnoses.

More signals coming
Additional organ protein signals for immune, pancreas, and other systems as we validate composites.
Coming next

We're just getting started.

The organ aging scores and protein signals are the foundation. What's being built on top of them goes deeper still.

Coming soon
🔬
Trained mechanistic subindices
ML models trained against clinical outcome labels — going from population-relative protein signals to validated predictions of specific pathological processes. Starting with liver and kidney.
Coming soon
🩺
Video consultation
A live video call with your Kale clinician to walk through your results in depth, answer questions, and discuss your health history in context. Currently available on request.
Coming soon
📋
Personalized health plan
Your clinician builds a targeted plan around your specific organ profile — lifestyle, nutrition, supplements, and prescription medication where clinically indicated. Retest to track whether it's working at the molecular level.
The bigger vision

A preventive health clinic built around your biology.

Most clinics are organized around disease. Kale is organized around you — your specific organ profile, your trajectory over time, and the interventions that actually move your numbers.

👩‍⚕️
Your Kale Clinician
Licensed NP · Preventive Health
Reviews your organ aging report and explains what's driving each score
Builds a prevention plan specific to your biology, not a generic protocol
Stays with you across retests — tracking your trajectory over time
Refers to specialists when signals warrant it — before symptoms appear

Be first to know
when Kale launches.

We're building toward a 2026 launch. Join the waitlist and we'll be in touch when early access is available.

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